Pompe disease is a lysosomal storage disorder in which acid alpha-glucosidase is deficient or absent.Deficiency of this lysosomal enzyme results in progressive expansion of glycogen-filled lysosomes in multiple tissues, with cardiac and skeletal muscle being the most severely affected.The clinical spectrum ranges from fatal hypertrophic cardiomyopa

Abstract Background It has been suggested that Plethodontid salamanders are excellent candidates for SWEETS indicating ecosystem health.However, detailed, long-term data sets of their populations are rare, limiting our understanding of the demographic processes underlying their population fluctuations.Here we present a demographic analysis based on